Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide
Identifieur interne : 001163 ( Main/Exploration ); précédent : 001162; suivant : 001164Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide
Auteurs : Frances Flanagan [Irlande (pays)] ; Louisa Glackin [Irlande (pays)] ; Dubhfeasa M. Slattery [Irlande (pays)]Source :
- Pediatric Pulmonology [ 8755-6863 ] ; 2013-03.
Descripteurs français
- KwdFr :
- Cyclophosphamide (administration et posologie), Cyclophosphamide (usage thérapeutique), Enfant, Humains, Hémosidérose (diagnostic), Hémosidérose (traitement médicamenteux), Immunosuppresseurs (administration et posologie), Immunosuppresseurs (usage thérapeutique), Maladies pulmonaires (diagnostic), Maladies pulmonaires (traitement médicamenteux), Mâle, Perfusions veineuses.
- MESH :
- administration et posologie : Cyclophosphamide, Immunosuppresseurs.
- diagnostic : Hémosidérose, Maladies pulmonaires.
- traitement médicamenteux : Hémosidérose, Maladies pulmonaires.
- usage thérapeutique : Cyclophosphamide, Immunosuppresseurs.
- Enfant, Humains, Mâle, Perfusions veineuses.
English descriptors
- KwdEn :
- Child, Cyclophosphamide (administration & dosage), Cyclophosphamide (therapeutic use), Hemosiderosis (diagnosis), Hemosiderosis (drug therapy), Humans, Immunosuppressive Agents (administration & dosage), Immunosuppressive Agents (therapeutic use), Infusions, Intravenous, Lung Diseases (diagnosis), Lung Diseases (drug therapy), Male.
- MESH :
- chemical , administration & dosage : Cyclophosphamide, Immunosuppressive Agents.
- chemical , therapeutic use : Cyclophosphamide, Immunosuppressive Agents.
- diagnosis : Hemosiderosis, Lung Diseases.
- drug therapy : Hemosiderosis, Lung Diseases.
- Child, Humans, Infusions, Intravenous, Male.
Abstract
Idiopathic pulmonary hemosiderosis (IPH), a subtype of diffuse alveolar hemorrhage is a rare condition, first described by Virchow in 1864. Historically, it manifests in children in the first decade of life with the combination of hemoptysis, iron deficiency anemia, and alveolar infiltrates on chest radiograph. More recently, diffuse alveolar hemorrhage has been classified by the absence or presence of pulmonary capillaritis (PC), the latter carrying a potential for a poorer outcome. While systemic corticosteroids remain the first line treatment option, other immune modulators have been trailed including hydroxychloroquine, azathioprine, 6‐mercaptopurine, and cyclophosphamide with varying results. Our case demonstrates for the first time, the successful use of intravenous cyclophosphamide in the management of chronic idiopathic PC. Pediatr Pulmonol. 2013; 48:303–305. © 2012 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/ppul.22583
Affiliations:
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